Enhanced DNA binding of 9-w-amino alkyl ether analogs of plant alkaloid berberine. Islam Md. M. Basu, A Hossain, M., Suresh kumar, G., Hotha, S and Suresh Kumar, G. DNA Cell Biology 2011 Feb;30 2 :123-33
Therapeutic potential of nucleic acids binding isoquinoline alkaloids: Binding aspects and implications for drug design. Bhadra, K., and Suresh Kumar, G. Medicinal Research Reviews, 31: n/a. doi: 10.1002/med.20202
The influence of the structural orientation of amide linkers on the serum compatibility and lung transfection properties of cationic amphiphiles. Srujan, M.; Chandrashekhar, V.; Reddy, R. C.; Prabhakar, R.; Sreedhar, B.; Chaudhuri, A. Biomaterials. 2011 Aug;32 22 :5231-40.
Cationic Amphiphiles with Fatty Acyl Chain Asymmetry of Coconut Oil Deliver Genes Selectively to Mouse Lung. Chandrashekhar, V.; Srujan, M.; Prabhakar, R.; Reddy, R. C.; Sreedhar, B.; Rentam, K. R.; Kanjilal, S.; and Chaudhuri, A. Bioconjugate Chem. 2011, 22, 497-509.
Gene expression profiling indicate role of ER stress in miR-23a~27a~24-2 cluster induced apoptosis in HEK293T cells Ravindresh Chhabra, Richa Dubey and Neeru Saini RNA Biol. 2011 Jul 1;8 4 .
miRvar: A Comprehensive Database and Systematic Analysis of Genomic Variations in microRNAs Bhartiya D, Laddha, SV, Mukhopadhyay A, Scaria, V Human Mutation, 32: E2226–E2245
Probing the furanose conformation in the 20–50strand of isoDNA:RNA duplexes by freezing the nucleoside conformations Namrata Erande, Anita D. Gunjal, Moneesha Fernandes and Vaijayanti A. Kumar Chem. Commun., 2011, 47, 4007–4009
miR-29a levels are elevated in the db/db mice liver and its overexpression leads to attenuation of insulin action on PEPCK gene expression in HepG2 cells. Pandey AK, Verma G, Vig S, Srivastava S, Srivastava AK, Datta M. Mol Cell Endocrinol. 2011 Jan 30;332(1-2):125-33.
Consensus miRNA expression profiles derived from interplatform normalization of microarray data Rhishikesh Bargaje, Manoj Hariharan, Vinod Scaria, and Beena Pillai RNA 2010 16: 16-25
Sampling the Structure of the Non-Canonical Lin-4:Lin-14 MicroRNA:mRNA Complex by Molecular Dynamics Simulations Balasubrmanian, B.; Ojha, R.; Maiti, S.; Desideri, A. J. Phys. Chem. B, 2010, 114 49 , pp 16443–16449
Locked onto the Target: Increasing the efficiency of antigomirzymes using LNA – modifications Kaur, H.; Scaria, V.; Maiti, S. Biochemistry 2010, 49, 9449-56
Modulation of microRNA function by synthetic ribozymes Suryawanshi. H.; Scaria, V.; Maiti, S. Mol Biosyst 2010, 7, 1481-6.
Thermodynamics of Peptide-RNA Recognition: The Binding of a Tat Peptide to TAR RNA Suryawanshi, H; Sabharwal, H; Maiti, S. J. Phys. Chem-B2010, 114, 11155-11163
Binding of the benzophenanthridine alkaloid sanguinarine to double stranded RNA polynucleotides: New insights into the structural aspects and energetics of interaction. Roy Chowdhury, S., Islam M. M. and Suresh Kumar, G. Mol. BioSystems 2010 6, 1265-1276
Molecular recognition of poly(A) by targeting by protoberberine alkaloids: In vitro biophysical studies and biological perspectives. Giri, P. and Suresh Kumar, G. Mol. BioSystems. 2010 6, 81-88.
Isoquinoline alkaloids and their binding with polyadenylic acid: Potential basis of therapeutic action. Giri, P. and Suresh Kumar, G.. Mini Rev. Med. Chem. 2010 10 7 , 568-577
Locked nucleosides based on oxabicyclo [3.2.1]octane and oxabicyclo [2.2.1] heptane skeletons, Ghosh, R.P, Maity, J.K, Achari, B. and Mandal, S.B.J. Org. Chem..2010, 75, 2419-2422
A synthetic route to fully substituted chiral cyclopentyl amine derivatives: precursors of carbanucleosides. Ghosh, R.P, Maity, J.K, Drew, M.G.B. Achari, B. and Mandal, S.B. Synthesis 2010 1303-1310
Synthesis of carbohydrate derived 1-oxaspiro[4.4]nonane skeleton and its conversion to spironucleosides Maity, J.K, Achari, B,. Drew,M.G.B., Mandal, S.B. Synthesis 2010 2533-2542
Sequence-selective binding of phenazinium dyes phenosafranin and safranin O to guanine-cytosine deoxyribopolynucleotides: spectroscopic and thermodynamic studies. Saha, I., Hossain, M and Suresh Kumar G. J Phys Chem B. 2010 Nov 25;114 46 :15278-87
MicroRNA-128 downregulates bax and induces apoptosis in human embryonic kidney cells. Yogita K Adlakha and Neeru Saini Cell Mol Life Sci.2010 2011 Apr;68 8 :1415-28.
Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases. Chhabra R, Dubey R, Saini N. Mol Cancer 2010, Sep 3, 9, 232
Cationic amphiphile with shikimic acid head-group shows more systemic promise than its mannosyl analog as DNA vaccine carrier in dendritic cell based genetic immunization. Srinivas, R.; Karmali, P. P.; Pramanik, D.; Garu, A.; Mahidhar, Y. V.; Majeti, B. K.; Ramakrishna, S.; Srinivas, G.; Chaudhuri, A.J. Med. Chem. 2010,53,1387-1391.
The use of RGDGWK-lipopeptide to selectively deliver genes to mouse tumor vasculature and its complexation with p53 to inhibit tumor growth. Samanta, S.; Ramakrishna, S.; Chaudhuri, A. Biomaterials2010, 31, 1787-1797.
Probing Binding Preferences of DNA and RNA:Backbone Chirality of Thioacetamido-Linked Nucleic Acids and iso-Thioacetamido-Linked Nucleic Acids to Differentiate DNA versus RNA Selective Binding Sachin S. Gokhale, Khirud Gogoi, and Vaijayanti A. Kumar J. Org. Chem. 2010, 75, 7431–7434
Design, synthesis and DNA/RNA binding studies of nucleic acids comprising stereoregular and acyclic polycarbamate backbone: polycarbamate nucleic acids (PCNA) Vangala Madhuri and Vaijayanti A. Kumar Org. Biomol. Chem., 2010, 8, 3734–3741
Amino/guanidino-functionalized N-(pyrrolidin-2-ethyl)glycine-based pet-PNA: Design, synthesis and binding with DNA/RNA Sachin S. Gokhale and Vaijayanti A. Kumar Org. Biomol. Chem., 2010, 8, 3742–3750
Incomplete penetrance and variable expressivity: is there a microRNA connection? J. K. Ahluwalia, M. Hariharan, R. Bargaje, B. Pillai, and V. Brahmachari Bioessays. 2009 . 31, 981-992.
MicroRNAs in Diabetes: Tiny Players in Big Disease A. K. Pandey, P. Agarwal, K. Kaur and M. Datta Cell Physiol Biochem. 2009. 23[4-6], 221-232.
Prediction of viral microRNA precursors based on human microRNA precursor sequence and structural features. S. Kumar, F.A. Ansari and V. ScariaVirology Journal 2009, 6:129.
Upregulation of miR-23a,27a,24-2 Cluster Induces Caspase-Dependent and -Independent Apoptosis in Human Embryonic Kidney Cells R. Chhabra., Y.K. Adlakha., M. Hariharan, V.Scaria, N. Saini PLoS ONE 2009, 4, 848
dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation M. Hariharan, V. Scaria and S.K. Brahmachari BMC Bioinformatics 2009, 10,108
Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence microRNA Function V. M. Jadhav, V. Scaria, and S. Maiti Angew. Chem. Int. Ed. 2009, 48, 2557 –2560
Effects for the Incorporation of Five-atom Thioacetamido Nucleic Acid (TANA) Backbone on Hybridization Thermodynamics and Kinetics of DNA Duplexes H. Kaur, A. Arora, K. Gogoi, P. Solanke, A. D. Gunjal, V. A. Kumar and S. Maiti J. Phys. Chem. B 2009, 113, 2944–2951
Small molecule–RNA interaction: Spectroscopic and calorimetric studies on the binding by the cytotoxic protoberberine alkaloid coralyne to single stranded polyribonucleotides Md. M. Islam, G. S. Kumar Biochimica et Biophysica Acta 2009, 1790, 829–839
Molecular Aspects of Small Molecules-Poly(A) Interaction: An Approach to RNA Based Drug Design P. Giri, and G. S. Kumar Current Medicinal Chemistry, 2009, 16, 965-987
Interaction of Small Molecules with Double-Stranded RNA: Spectroscopic, Viscometric, and Calorimetric Study of Hoechst and Proflavine Binding to PolyCG Structures R. Sinha, M. Hossain, and G.S. Kumar DNA and Cell Biology, 2009,28, 209–219
Spectroscopic and Calorimetric Studies on the Binding of Alkaloids Berberine, Palmatine and Coralyne to Double Stranded RNA Polynucleotides Md. M. Islam, S. R. Chowdhury, and G. S. Kumar J. Phys. Chem. B 2009, 113, 1210–1224
RNA targeting through binding of small molecules: Studies on t-RNA binding by the cytotoxic protoberberine alkaloid coralynew Md. M. Islam, P. Pandya, S. Kumar and G.S. Kumar Mol. BioSyst., 2009, 5, 244–254
Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver R. Mukthavaram, R. Marepally, A.Y. Venkata, N.N. Vegi, R. Sistla, A.Chaudhuri Biomaterials, 2009, 30, 2369–2384
Selective Cancer Targeting via Aberrant Behavior of Cancer Cell-associated Glucocorticoid Receptor A. Mukherjee, K. P Narayan, R. Pal1, J.M. Kumar, N. Rangaraj, S. V Kalivendi and R. Banerjee1 Molecular Therapy 2009, 17 , 623–631 .
Methyl glycosides are identified as glycosyl donors for the synthesis of glycosides, disaccharides and oligosaccharidesw S. R. Vidadala and S. HothaChem.Commun., 2009, 2505–2507
Interaction of isoquinoline alkaloids with RNA triplex: Structural and thermodynamic studies of berberine, palmatine, and coralyne binding to poly(U).poly(A)*poly(U). Sinha, R. and Suresh Kumar, G J. Phys. Chem. B. 2009 113, 13410-13420.
Cationic Amphiphiles: Promising Carriers of Genetic Materials in Gene Therapy. Ramishetti Srinivas, Sanjoy Samanta and Arabinda Chaudhuri.Chemical Society Reviews 2009, 38, 3326-3338
Effect of chirality of L/D-proline and prochiral glycine as the linker amino acid in five-atom linked thymidinyl-(a-amino acid)-thymidine dimers Seema Bagmare, Moneesha D’Costa and Vaijayanti A. Kumar Chem. Commun., 2009, 6646–6648
MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Roshan,R., Ghosh,T., Scaria,V., and Pillai,B. Drug Discov. Today. (2009). 14, 1123-1129.
Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication J. K Ahluwalia1, S. Z. Khan, K.Soni, P. Rawat, A. Gupta, M. Hariharan, V. Scaria, M. Lalwani1, B. Pillai, D. Mitra and S. K. Brahmachari Retrovirology 2008, 5:117
MicroRNA-mediated up-regulation of an alternatively polyadenylated variant of the mouse cytoplasmic b-actin gene T. Ghosh, K.Soni, V. Scaria, M. Halimani, C. Bhattacharjee and B. Pillai Nucleic Acids Research, 2008, 36, 196318–6332
Binding of DNA-binding alkaloids berberine and palmatine to tRNA and comparison to ethidium: Spectroscopic and molecular modeling studies Md. M. Islam, P. Pandya, S. R. Chowdhury, S. Kumar, G. S. Kumar Journal of Molecular Structure, 2008, 891, 498–507
Introduction of Vinyl and Hydroxymethyl Functionalities at C-4 of Glucose-Derived Substrates: Synthesis of Spirocyclic, Bicyclic, and Tricyclic Nucleosides J.K. Maity, R. Ghosh, M. G. B. Drew, B.Achari, and S. B. Mandal, J. Org. Chem. 2008, 73, 4305–4308
Lipopeptide with a RGDK Tetrapeptide Sequence Can Selectively Target Genes to Proangiogenic 5-1 Integrin Receptor and Mouse Tumor Vasculature D. Pramanik, B. K. Majeti, G. Mondal, P.P.Karmali, R. Sistla, O.G. Ramprasad, G.Srinivas, G.Pande, and A.Chaudhuri J. Med. Chem. 2008, 51, 7298–7302
Covalent Grafting of Common Trihydroxymethylaminomethane in the Headgroup RegionImparts High Serum Compatibility and Mouse Lung Transfection Property to Cationic Amphiphile K. Mukherjee, J.Bhattacharyya, J.Sen, A. Sistla, and A. Chaudhuri J. Med. Chem. 2008, 51, 1967–1971
microRNAs in viral oncogenesis V. Scaria and V. Jadhav Retrovirology 2007, 4,82